Volumetric Bioprinting (VBP) enables fast photopolymerization of three-dimensional (3D) constructs by illuminating dynamically evolving light patterns in the entire build volume. We develop a VBP device that uses green visible light to print complex structures in a few seconds (as low as 10s), while cell-loaded bioinks envelope high cell activity (> 90%) after printing. The printed biostructures and uncured bioinks can also be easily separated and recycled.

We investigate rapid volumetric (bio)printing of pristine, unmodified silk-based (silk sericin (SS) and silk fibroin (SF)) (bio)inks to form sophisticated shapes and architectures. Both types of silk-based (bio)inks are cytocompatible. We also investigate the compatibility of pristine, unmodified heart-derived dECM (h-dECM) and meniscus-derived dECM (Ms-dECM) combined with Ru/SPS as a new class of bioinks for volumetric bioprinting. Low concentrations of dECM allow for fast printing and high cellular activity.

We develop multiple forms of drug carriers, such as microneedles, nanoparticles and exosomes, with efficient drug loading and delivery capabilities, which achieve the effect of treating a variety of tumors.